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Whitepaper

SLT: The Duality of SLT in Glaucoma Management

This whitepaper explores the diagnostic and treatment roles of selective laser trabeculoplasty (SLT) in glaucoma management.

This whitepaper explores the diagnostic and treatment roles of selective laser trabeculoplasty (SLT) in glaucoma management. Whilst many studies have reviewed the evidence for SLT as a primary or adjunct therapy, the benefit derived from SLT as a diagnostic aid when used as first-line therapy is something that is only now beginning to be explored. One of the biggest challenges in managing glaucoma is accurately determining the location of blockages within the outflow system.

SLT works by applying selective photothermolysis to the pigmented trabecular meshwork cells, releasing proteins and cytokines which improve the circulation of aqueous humor through the trabecular meshwork and the inner wall of the Schlemm’s canal. This mechanism of action allows physicians to estimate the location of the pathology based on the outcome of SLT: if SLT is effective, the physician can deduce that the primary region of obstruction lies within the trabecular meshwork. In contrast, if SLT proves ineffective, then the primary obstruction may reside outside the trabecular meshwork. Not only is this helpful in understanding the patient’s pathology, but it can also provide key information regarding the potential efficacy of future treatments.

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